2021年3月5日，据欧盟食品安全局（EFSA）消息，应欧盟委员会要求，欧盟动物饲料添加剂和产品（FEEDAP）研究小组就地衣芽孢杆菌DSM19670生产的丝氨酸蛋白酶（serineprotease）作为鸡育肥饲料添加剂的安全性和有效性发表科学意见。经过评估，专家小组得出结论，该添加剂对鸡育肥是安全的。
在没有数据的情况下，无法得出有关皮肤致敏潜力的结论。当添加剂使用水平为15,000PROT/kg饲料对鸡育肥有效。部分原文报道如下：Ronozyme®ProActisthetradenameofthefeedadditiveunderassessmentandcontainsserineproteaseproducedbyageneticallymodifiedstrainofBacilluslicheniformis.FollowingarequestfromtheEuropeanCommission,thePanelonAdditivesandProductsorSubstancesusedinAnimalFeed(FEEDAP)wasaskedtodeliverascientificopiniononthesafetyandefficacyofRonozyme?ProActwhenusedasazootechnicaladditiveforchickensforfattening.Theadditiveisavailableincoatedthermotolerantgranulatedandliquidforms(Ronozyme®ProActCT/L).TheproductionstrainanditsrecombinantDNAwerenotdetectedinanintermediateconcentratedproductusedtoproducethefinalformulations.Thefinalproductsdonottriggerasafetyconcernwithregardtothegeneticmodification.basedontheresultsobtainedinatolerancestudyinchickensforfatteningandthedatafromasubchronicoraltoxicitystudytheFEEDAPPanelconcludedthattheadditiveissafeforchickensforfattening.TheFEEDAPPanelconcludedthattheuseofRonozyme®ProActCT/Lasafeedadditivegivesrisetonoconcernforconsumersandfortheenvironment.Theadditive,ineitherform,isnotaneyeirritantbutshouldbeconsideredaskinirritant.Intheabsenceofdata,noconclusionsontheskinsensitisationpotentialcanbereached.Owingtotheproteinaceousnatureoftheactivesubstanceitshouldbeconsideredarespiratorysensitiser.TheFEEDAPPanelalsoconcludedthattheadditivehasthepotentialtobeefficaciousat15,000PROT/kgcompoundfeedforchickensforfattening.有任何疑问，请联系。
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